Kutaura nezvazvoberberine , munhu wese angave asina kujaira, asi munhu wese anofanira kuziva chirevo chaanoziva: Munhu mbeveve anodya coptis - haazive kurwadziwa! Ndizvozvo, chikamu chikuru chinovava mucoptis iberberine, iyo inonzi berberine hydrochloride.
Berberine (BBR) is isoquinoline alkaloid - C20H19NO5 yakatorwa kubva kuCoptis chinensis. Inowanikwa mumiti ye10 genera uye 4 mhuri dzinosanganisira Berberidaceae. Makristasi eyero akaita setsono anogona kunayiwa kubva kudiethyl ether, aine nzvimbo yekunyungudika inosvika 145°C. Izvo zvinonyungudika mumvura uye zvisinganyunguriki mubenzene, diethyl ether uye chloroform.
Ongororo yemazuva ano yemishonga yakasimbisa kuti berberine ine zvakakosha zvinopesana nemoyo kukundikana, anti-arrhythmia, kuderedza cholesterol, anti-vascular smooth muscle proliferation, kuvandudza insulin resistance, anti-platelet, anti-inflammatory nezvimwe zvinokonzerwa. Nokudaro, inogona kubatsira muhutano hwemwoyo uye nervous system zvirwere. Yayo yakakura uye yakakosha tarisiro yekushandisa yakakwezva kuwedzera kutarisisa. Maererano netsvakiridzo yekiriniki yazvino, berberine ine mhedzisiro yakanaka pakudzivirira nekurapa hypertension, hyperlipidemia, chirwere cheshuga, arrhythmia, tumors nezvimwe zvirwere. Berberine hydrochloride yakashumwa zvakanyanya mukuderedza ropa lipids. BBR inogona kudzora kutaura kweyakaderera-density lipoprotein receptor LDLR uye kukurudzira kutorwa kweLDL protein nemasero echiropa. BBR inoshandurwa kuita dihydroberberine (dhBBR) ne nitroreductase yemudumbu flora gut microbiota, zvichiita kuti inyudzwe nyore nematumbu. Mushure mekutora, inoiswa oxidized muBBR mumatumbo emukati uye inopinda muropa. Wana lipid-kudzikisa uye hypoglycemic mhedzisiro. BBR inogonawo kuvandudza simba remagetsi. Oral administration yeBBR inoita kuti gut microbiota igadzire butyrate, inopinda muropa uye ichiita paSCFAs (short chain fatty acids), ichideredza ropa lipids uye mazinga eshuga.
BBR inogona kukurudzira kuvandudzwa kwepancreatic islet masero uye ine zvakawanda zvakanakira kupfuura mamwe anti-diabetic zvinodhaka. Miedzo yekliniki yakakodzera yakaratidza kuti berberine inogona kudzivisa myocardial fibrosis mumakonzo ane chirwere cheshuga; BBR ine anti-platelet mhedzisiro, inogona kuwedzera nucleotide yemukati mumaplatelet uye inhibit kuungana. Berberine yakasanganiswa nema statins inoita basa rakakosha mukudzikamisa plasma trimethylamine oxidation mucoronary heart disease uye kuvharidzira kuumbwa kweatherosclerosis.
Chinese berberine inzira yakanaka kune "statin" mishonga. Sezvo berberine yakachipa kakawanda kupfuura mishonga ye “statins”, kuwanikwa kweberberine's blood-lipid-lowing effect ine kukosha kusingafungidzirwe pakudzivirira nekurapa hyperlipidemia, chirwere cheshuga uye chirwere chemoyo.
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Nguva yekutumira: Jan-08-2024
