NAD Pre-Cursor sumo

NAD+ yakakosha coenzyme, ine zita rizere nicotinamide adenine dinucleotide. Inowanikwa zvakanyanya mukati memasero uye inotora chikamu mune zvakawanda zvakakosha biochemical reaction. NAD + inoita basa rakakosha mumaitiro mazhinji ebhayoloji, anosanganisira simba metabolism, kufema kweserura, kugadzirisa kweDNA, kunyorwa kwemajini, uye kuchembera. Inogona kuwana kana kusunungura maerekitironi kubva mairi kuburikidza nemhando dzakasiyana dze biocatalytic reactions. Mukuita uku, maitiro anogona kukonzeresa NAD + anosanganisira redox, carbonyl kuderedza, acyl transfer, etc. Secoenzyme, basa guru reNAD ​​+ ndere kuendesa maerekitironi nehydrogen ions mune enzyme-catalyzed reactions. Munguva iyi, NAD+ inoderedzwa kuita NADH, nekudaro ichipa maerekitironi nehydrogen ions kune mamwe ma enzyme anodiwa maitiro. NAD+ yakakwezvawo kutarisisa kwesainzi mumakore achangopfuura nekuti inofungidzirwa kuve nechekuita mukuchembera. Zvidzidzo zvakaona kuti panguva yekuchembera, mwero weNAD + mumasero unodzikira, uye kuwedzera NAD + kunogona kusimudzira cellular simba metabolism, kugadzirisa kweDNA uye kunonoka kuchembera. Pamusoro pezvo, NAD + yakawanikwa zvakare ichiita basa rakakosha mukugadzirisa kukuvara kweDNA, apoptosis, activate enzymes uye kudzora gene kutaura. Parizvino, vanhu vari kuita tsvakiridzo yakadzama paNAD+ nebasa rayo muphysiology uye pathology, kuitira kuti vawane zvakawanda nezvemabasa nemashandisirwo eNAD+.