Tiye chikamu chechipiri
Hukama pakati peNAD + nechirwere:
Zvironda zvinokonzerwa neabnormal NAD + metabolism
01.NAD + uye utachiona
Parizvino zvinozivikanwa kuti kutapukirwa nemavhairasi akati wandei kunokonzeresa kudzikira kwakanyanya n kugadzirisa kukuvadzwa nekuita maPARPs, nekudaro kubvisa mavhairasi uye kurwisa hutachiona.
02.NAD+ nekuchembera
Tsvagiridzo inoratidza kuti mazinga eNAD + emuviri anodzikira nezera. Kudzikira kweNAD + mazinga ndechimwe chezvinhu zvikuru mukusashanda zvakanaka kwebiological uye kuchawedzera kuchembera. Miedzo yakaratidza kuti kuwedzera NAD + kunogona kunonoka kuchembera.
03. Kuderera kweNAD + kunokonzera kusagadzikana kwemitochondrial
Mitochondrial dysfunction ndechimwe chezviratidzo zvekuchembera, uye kushomeka kweNAD + ndicho chikonzero chakakosha chechiitiko ichi. Kudzoreredza mazinga eNAD + kuburikidza neNAD + yekuwedzera uye dzimwe nzira dzinogona kuvandudza zvakanyanya mitochondrial basa.
04.NAD+ uye oxidative kusagadzikana
Kuchengeta yakajairwa NADH/NADPH reshiyo kunogona kuderedza zvakanyanya cellular oxidative kusagadzikana, uye NAD + ndiyo musimboti wekudzora reshiyo iyi.
.05.NAD+ uye circadian rhythm
Kuwedzera NAD + uye kuwedzera muviri NAD + zvirimo zvinhu zvinodiwa kuti maseru achengetedze circadian rhythm.
.06.NAD + uye metabolic zvirwere
Kune vanhu vane Type 2 chirwere cheshuga, kufutisa uye isiri-doro mafuta ane chiropa chirwere, iwo NAD + mazinga mumasero avo enyama anodzikira zvakanyanya. NAD + yekuwedzera inogona kuwedzera NAD + mazinga, nekudaro ichivandudza mamiriro eaya matatu metabolic zvirwere.
07.NAD + uye kutadza kwetsvo
Mukuedza mbeva nekutadza kwerenal, zvakaonekwa kuti NAD+ yakanga yadzikira zvakanyanya, uye kugona kweNAD+ muitsvo kwakadzikirawo, zvichikonzera kudzikira kwemazinga eNAD+..Pamusoro pezvo, NAD + inoitawo basa rakakosha mumhando dzakasiyana dzezvirwere zveurourodegenerative uye chirwere chemoyo.
chikamu chechitatu
Batsira kuzadza NAD+ neNMN
. NAD+ icoenzyme yemazana emazana emakemikari akakosha emetabolism mumasero, uye anotora chikamu mune akawanda akakosha maserura maitiro seaisaina mamorekuru, ane hukama zvakanyanya nesimba metabolism, glycolysis, DNA kudzokorora uye zvimwe zviitiko. Uye mazhinji emamiriro ari pamusoro haana kupatsanurika kubva mukutora chikamu kweNAD +, saka kuwedzera NAD + kwakakosha.
NAD+ precursor: NMN
Tinogona kuwedzera mazinga eNAD + evanhu nekutora NMN nemuromo. NMN ndiyo inotungamira yekubatanidza kweNAD + (coenzyme I) mumuviri wemunhu. Huwandu hwekuedza kwemhuka hwakaratidza kuti NMN inogona kukurumidza kuwedzera mwero weNAD+ mumaseru uye yakachengeteka zvakanyanya.
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Nguva yekutumira: Zvita-26-2023
