Berberine hydrochloride

Iyo ine inhibitory mhedzisiro paEscherichia coli, Escherichia coli, Diplococcus pneumoniae, Staphylococcus aureus, Streptococcus, Typhi uye amoeba. Clinically, inonyanya kushandiswa kuparadza zvirwere uye mabhakitiriya. Yakawanikwa zvakare kuti chigadzirwa ichi chine anti-arrhythmic effect. Berberine ine anti-tumor basa mu vitro uye inogona kukonzera secretion yeB16 masero; zvakafanana ne cytarabinehydrochlorideine mhedzisiro yakanaka in vitro.

Chinangwa
Isoquinoline alkaloid. Molecular formula [C20H18NO4]+. Iyo inozivikanwawo seberberine. Inowanikwa mumiti yakawanda muzvikamu gumi uye mhuri ina kusanganisira Berberidaceae. Berberine inogona kukonzeresa yero yetsono-kunge makristasi kubva kudiethyl ether. Kunyungudika 145 ℃. Soluble mumvura, isinganyunguriki mubenzene, ether uye chloroform. Berberine inonzi quaternary ammonium alkaloid, uye kunyungudika kwemunyu wayo mumvura kuduku, somuenzaniso, hydrochloride iri 1:500 uye sulfate i1:30. Makristasi eberberine anodonha kubva mumvura kana dilute ethanol ane 5.5 mamorekuru emvura yekristaro; kana yakanamirwa kubva kukloroform, acetone kana benzene, ine zvakare inoenderana necrystallization solvent molecules. Berberine inogona kurapwa nealkali yakasiyana kuti iwane marudzi matatu akasiyana eberberine: quaternary ammonium fomu, aldehyde fomu uye doro fomu, pakati peiyo quaternary ammonium fomu ndiyo yakanyanya kugadzikana. Berberine ine antibacterial mhedzisiro pahemolytic Streptococcus, Staphylococcus aureus, Neisseria gonorrhoeae, Freundii uye Shigella dysenteriae, uye inosimudzira phagocytosis yemasero machena eropa. Berberine hydrochloride (inowanzozivikanwa seberberine hydrochloride) yakashandiswa zvakanyanya kurapa gastroenteritis, bacillary dysentery, nezvimwewo, uye zvakare ine zvimwe zvinokonzeresa tibhii, scarlet fever, acute tonsillitis uye zvirwere zvekufema.

pharmacology
pharmacodynamics
Iyo ine yakakura antibacterial spectrum uye ine antibacterial mhedzisiro pane akasiyana siyana eGram-positive uye -negative mabhakitiriya in vitro, kusanganisira hemolytic Streptococcus, Staphylococcus aureus, uye Vibrio cholerae. Meningococci, Shigella dysenteriae, typhoid bacilli, Diphtheria bacilli, nezvimwewo zvine simba rinodzivisa. Ivo vane bacteriostatic pakadzika kudzika uye sterilizing pakakwirira. Iyo inewo mamwe inhibitory mhedzisiro pamavhairasi efuruwenza, amoeba, leptospira, uye mamwe fungus eganda. In vitro miedzo yakasimbisa kuti berberine inogona kuwedzera kugona kwephagocytic yeleukocytes uye chiropa reticuloendothelial system. Shigella dysenteriae, hemolytic Streptococcus, Staphylococcus aureus, nezvimwewo zviri nyore kupikisa chigadzirwa ichi. Hapana kupesana-kupikisa pakati pechigadzirwa ichi nepenicillin uye streptomycin.

Pharmacokinetics
Kusabatwa zvakanaka nemuromo. Mushure mejekiseni, inokurumidza kupinda munhengo dzakasiyana-siyana uye matishu, uye kuiswa kweropa kunochengetwa kwenguva pfupi. Kuwanda kweropa mushure mejekiseni re intramuscular yakaderera pane zvishoma inhibitory concentration. Mushonga unoparadzirwa zvakanyanya, zvakanyanya mumoyo, mapfupa, mapapu uye chiropa. Nguva yekuchengeta mumatishu ipfupi, uye ingori nhamba inosara mushure memaawa makumi maviri nemana. Mazhinji emishonga inogadziriswa uye inobviswa mumuviri, uye chete isingasviki 5% yedhesi inopihwa inoburitswa muchimiro chepakutanga mukati maawa makumi mana nemasere.
Maererano nemishumo ichangobva kuitika, inofungidzirwa kuti chigadzirwa ichi chinogona kuderedza nhamba yepiriri pamusoro pebhakitiriya, kudzivirira mabhakitiriya kuti asanamatira kumasero evanhu, uye ane maitiro ekurapa. Ichi chigadzirwa chinewo simba paHelicobacter uye chinogona kuderedza gastritis, gastric uye duodenal ulcers.

Yakaremara uye inoshandiswa nekuchenjerera
Kunyange zvazvo inogona kushandiswa muvana, inopesana nevana vane nhaka yeglucose-6-phosphate dehydrogenase inoshaya nokuti chigadzirwa ichi chinogona kukonzera hemolytic anemia uye kutungamirira kune jaundice.

Maitiro asina kunaka
1
(2) Jekiseni remutsinga kana kuisirwa zvinogona kukonzera kuita senge vasodilation, kudonha kweropa, uye kuora mwoyo. Mumatambudziko akaoma, Aspen syndrome inogona kuitika, uye kunyange rufu. China yakazivisa kubviswa kwemajekiseni akasiyana eberberine hydrochloride.
Vanhu vashoma vane dumbu rakapfava kana mudumbu kusagadzikana, kuvimbiswa kana manyoka.

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