Muna 1998, nyanzvi yeJapan Akiu et al. yakabviswa uye yakasarudzika arbutin kubva kumashizha ebearberry uye yakawana chinhu chinogona kuita chena mhedzisiro. Iine zvakasiyana-siyana zvemishonga zvakadai se anti-inflammatory, antibacterial, antitussive, expectorant, uye antiasthmatic. , iri zvakare inhibitor ye tyrosinase mu melanocytes yemunhu, saka yakakurumidza kuve inodiwa yeindasitiri yekuchena.
Arbutin, anozivikanwawo searbutin , ikemikari p-hydroxyphenyl-D-glucopyranoside uye iri muchimiro chekristaro chena setsono kana hupfu. Inonyungudika nyore mumvura inopisa, methanol, ethanol uye aqueous solutions yepropylene glycol uye glycerol, asi isingagadziriswi muether, chloroform, petroleum ether uye mamwe masolvents. Iyo molecular formula ndeye C12H16O7, uye chimiro chayo ndeichi:
Arbutin imorekuru inoumbwa nemapoka eorganic anoumbwa nepolyvalent hydroxyl mapoka. Mushonga wemvura hauna ruvara uye wakajeka, saka une kuenderana kwakanaka uye unogona kushandiswa nyore nyore sekuwedzera mumakirimu. Pamusoro pezvo, ine yakanaka yekunyorovesa zvivakwa, iri nyore kushandisa ne-makeup, ine ganda rakapfava uye rakasununguka kunzwa, uye ine zvishoma kuchena uye kuchena kunzwa mushure mekushandisa. Aya maitiro anotemerwa nechimiro chepolyhydroxyl glycosides.
Mukuwedzera, arbutin ine yakasarudzika inhibitory mhedzisiro pa melanin.
Melanin chinhu chakasviba che pigment chinogona kukonzera ruvara rweganda. Iyo inoumbwa neiyo oxidation ye tyrosine kuburikidza ne tyrosinase. Isu tinogona kuona tyrosinase seyakanyanya chiyero-inodzikamisa enzyme yekugadzirwa kwe melanin muganda. Basa re tyrosine rinotarisa huwandu hwe melanin yakaumbwa.
Maitiro ekudzivisa iyo catalytic chiitiko che tyrosinase ndiyo imwe yeakakosha nzira dzekutsvagisa muindasitiri yekuchena. Traditional whitening agents senge hydroquinone (1,4-hydroquinone) inogona kunyatso kuvharidzira kuita kwe tyrosinase uye kuve nekumwe depigmentation paganda. Zvisinei, kushandiswa kwekunze kunogona kukonzera kushatirwa uye kunogona kukonzera ganda kuvaviwa, kutema, uye kusvuura zviri nyore. Allergic zviratidzo zvakaita sedandruff uye erythema zvinogona kutokonzera kukuvara zvachose, saka kiriniki yekushandiswa kwayo inoenderana nezvimwe zvisingakwanisi.
Chimiro che arbutin chakafanana neicho chehydroquinone. Chimiro chayo chine mamwe mamorekuru eglucose kupfuura hydroquinone, zvichiita kuti ive yakagadzikana uye ine hushamwari hweganda. Iyo inogona zvakare kuvharisa zvinobudirira basa re tyrosinase uye kugadzirwa kwe melanin. , Aihwat chete inogona kubvisa tsvina, asiwo ine mamwe bactericidal uye anti-inflammatory effects.
Iyo ine yakaderera cytotoxicity uye yakachengeteka uye isina chepfu paganda. Inogona kunyatso kuvharidzira basa re tyrosinase uye kudzivirira kuumbwa kwe melanocytes. Inogona zvakare kusanganisa zvakananga ne tyrosinase kuti ikurumidze kuparara kwe melanin. uye kuburitsa kudzikisa kuiswa kwe melanin muganda, saka arbutin ndiyo yakanakira komputa vanhu vari kutsvaga.
Zvinoenderana nezvimiro zvakasiyana, arbutin inogona kukamurwa kuita α-arbutin, β-arbutin uye deoxyarbutin (D-arbutin).
Sezvo α-arbutin ichinyanya kuwanikwa kuburikidza nekushandurwa kwebiological uye enzymatic synthesis, uye chiyero chekugadzira chishoma, yakawanda yearbutin parizvino pamusika ndeye β-arbutin, asi kuchena mhedzisiro inongonaka sea-arbutin. Imwe-gumi neshanu.
Tsvagiridzo inoratidza kuti zvakafanira kuwedzera 3% arbutin kune zvizorwa, izvo zviri 90% zvinobudirira mukubvisa pigmenting freckles, butterfly spots uye melanin deposits.
Ose ari maviri α-arbutin uye β-arbutin anonyungudika mumvura, uye kaviri-layer lecithin chimiro chemunhu epidermal cell membrane inonyanya kubatsira pakutorwa kwemafuta-soluble components, saka deoxyarbutin yakatanga.
Nharembozha: 86 18691558819
Irene@xahealthway.com
www.xahealthway.com
Wechat: 18691558819
WhatsApp: 86 18691558819
Nguva yekutumira: Kubvumbi-12-2024
