Natural plant extraction method
Iyi nzira inonyanya kushandisa mashizha echirimwa eiyo genus Ursi semidziyo yakabikwa, uye inoshandisa organic solvent kudhirowa, kudhirowa, column chromatography uye dzimwe nzira dzekuparadzanisa uye dzekuchenesa kuwana.arbutin extract. Pakuvamba sa1930, kwakashumwa kutiarbutin iri mumashizha edombo makabheji. Ongororo dzakazotevera dzakasimbisa kuti arbutin inowanikwawo mumashizha emuti mutema mupunga, bilberry, bearberry uye pear tree. glycosides.
Sezvo zvinyorwa zve arbutin mumiti zvakaderera zvikuru, nzira yekuchera inenge yakaoma, uye kuchena kwechinyorwa hakuna kukwirira, saka nekuvandudzwa kwedzimwe nzira dzekugadzirira, nzira yekuchera chirimwa zvishoma nezvishoma yakarasikirwa nekukwikwidza kwayo.
Plant tissue culture
Iyo yechirimwa mutisu tsika nzira inoshandisa iyo glycosylation yemasero ezvirimwa kushandura hydroquinone kuita arbutin. Kuenzaniswa nemaitiro ekuchera chirimwa, kugona kwekuwana arbutin uchishandisa chirimwa tishu tsika nzira kwakakwira zvakanyanya. Paunenge uchishandisa iyi nzira, kusarudza inoshanda yechirimwa tsika yepakati uye kuona akakodzera tsika mamiriro kwakakosha.
T iye mbishi zvinhu zvinoshandiswa muchirimwa tishu tsika nzira dzakachena, mwero wekutendeuka wakakwira, uye kugadzirwa hakuna kusvibiswa. Nekudaro, kutenderera kwekugadzira kwakareba, kupatsanura uye kucheneswa kwakaomarara, uye budiriro yemaindasitiri haina kukura. Kuwedzera kunzwisisa nzira yekukura kwemasero ezvirimwa, kujekesa zvakakosha zvinopesvedzera zvinhu zveiyo synthesis process, kupfupisa kutenderera kwekugadzira, nekuvandudza goho ndizvo zvinhu zvakakosha zvinofanirwa kugadziriswa mukushandiswa kweiyi nzira.
Enzyme synthesis nzira
Iyo enzyme synthesis nzira inonyanya kushandisa glycosyltransferase kana glycosidase sechinhu chinokonzeresa kutamisa glycosyl uye kudzosera maitiro ehydrolysis kugadzira glycosides, kureva, arbutin inowanikwa kubva kuhydroquinone uye glucose pasi pecatalysis yeglycosidase.
Iyo enzyme synthesis nzira ine yakapusa maitiro, yakakwira synthesis kunyatsoshanda, uye tarisiro huru yebudiriro. Nekutsvagisa kwakadzama pamusoro peiyi nzira mumakore achangopfuura, akawanda uye akakodzera mazymogens akawanikwa, uye iyo synthesis rate ye arbutin iri kuramba ichikwira nekukwira. Zvinotendwa kuti iyi nzira ichave imwe yeanonyanya kutsvagisa dhairekitori yekubatanidza arbutin mune ramangwana. Poshi.
Chemical synthesis
Kazhinji, kemikari synthesis yearbutin inoshandisa glucose uye hydroquinone semidziyo. Mushure mekunge vaviri vacho vadzivirirwa zvakakodzera, vanopinda glycosidation reaction vobva vabvisa boka rinodzivirira. Iyo kemikari synthesis nzira yave yakanyanya kukosha nzira yekugadzirira arbutin nekuda kwemabhenefiti ayo ari nani ekugadzira chigadzirwa mhando uye yakaderera mutengo wekugadzira, uye yakawana kugadzirwa kwemaindasitiri kumba nekune dzimwe nyika.
Parizvino, muChina, anhydrous glucose inowanzoshandiswa seyakabikwa, uyeb -arbutin inogadzirwa kuburikidza nekuchengetedzwa kweacylation, catalytic condensation, uye alkaline hydrolysis. Nekuenderera mberi kwekuvandudza tekinoroji yekugadzira, mumakore achangopfuura, nhanho dzemumba yearbutin dzakarerutswa zvishoma nezvishoma, chiyero che synthesis chakaramba chichivandudzwa, uye hunhu hwasvika padanho repamusoro repasi rose. Nekudaro, nekuda kwekushomeka kwechigadzirwa mukugadzirwa kwemakemikari, tsvakiridzo yakadzama ichiri kudikanwa kuti uwane inoshanda uye yakananga makemikari synthesis nzira yekugadzirira.a-arbutin.
Kuchengeteka kweArbutin
Nekuti hydroquinone ine mhedzisiro yekuvharisa tyrosinase, yakashandiswa mukutanga anti-freckle uye whitening cosmetics kuderedza ganda pigmentation. Zvidzidzo zvakazoonekwa kuti hydroquinone ine njodzi yekukonzera exogenous ochronosis uye vitiligo, pamwe nekukurudzira uye carcinogenesis. Njodzi dzinogona kuitika, dzakanyorwa sechikamu chakarambidzwa chezvizoro munyika yangu. Arbutin zvakare iri tyrosinase inhibitor uye inotsiva hydroquinone. Mumamiriro ezvinhu akadai seyakaderera pH kukosha, kupisa kwakanyanya, uye ultraviolet irradiation, arbutin inogona kushandurwa kuita hydroquinone pasi pechiito cheganda tupukanana kana glucosidase, zvichikonzera njodzi dzinogona kuitika dzekunzwa, genotoxicity, kana carcinogenesis. Naizvozvo, tsvakiridzo yekuchengetedza yearbutin yagara ichikwezva kutarisisa kweindasitiri.
Muna Kukadzi 2023, SCCS yakabudisa maonero ayo ekupedzisira pamusoro pekuchengetedzwa kwea-arbutin uyeb-arbutin muzvizoro (SCCS/1642/22), ine mhedziso dzinotevera
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